Translating Genomics into Better Medicine
William F. Crowley, Director of Clinical Research, Massachusetts General Hospital; Co-Director of Clinical Research, Partners HealthCare
Judy Garber, Clinical Investigator, Dana Farber Cancer Institute; Associate Professor of Medicine, Harvard Medical School
Dr.
Hilary Worthen, Internist, Cambridge Hospital
Instructor in Medicine
at HMS
Dr.Bruce Korf, Medical Director Center for Human Genetics, Partners HealthCare, MODERATOR
This panel will discuss the implications of the HGP for clinical and investigative medicine. Many myths surround the role of genetics in our lives. While the HGP holds great promise, how realistic are our expectations? This panel address the translation of genetic research into scientific knowledge, and this knowledge into medical practice. Specifically, we will consider how genomics will impact clinical research and the patient-doctor relationship. Importantly, the panel will focus on the necessity of inter-agency collaboration in the post-genomic world. The discussion will include four speakers, each of whom will address the present and future of genetics in medicine.
Our Speakers come from a variety of backgrounds and interests, yet all contribute a critical perspective in advancing and translating the progress of the Human Genome Project into applicable medicine.
Questions to be considered:
- What kinds of clinical diagnostics and therapies may result from HGP, and for what types of diseases?
- How will the scientific complexity of the HGP be translated from scientist to doctor to patient?
- Will new knowledge from the HGP lead to mass screening for genetic diagnosis of diseases?
- What role do our genes play in determining our quality of life, and is there anything that can be done to change our genetic makeup?
Relevant Articles
1:
Collins FS, Mansoura MK.
The Human Genome Project.
Cancer. 2001 Jan 1;91(S1):221-225.
[Record as supplied by publisher] PMID: 11148583
2:
Swartz K.
The human genome and medical care in the new century. Inquiry.
2000 Spring;37(1):3-6. No abstract available.
PMID: 10892353; UI: 20350274
3:
Lander ES.
Scientific commentary: the scientific foundations and medical and
social prospects of the Human Genome Project.
J Law Med Ethics. 1998 Fall;26(3):184-8,
178.
PMID: 11066875; UI: 20433916
4:
Weber DO.
Proteomics: the next frontier.
Health Forum J. 2000 May-Jun;43(3):20-2.
No abstract available.
PMID: 11010152; UI: 20416754
5:
Lemonick MD.
The genome is mapped. Now what? It will be decades before scientists
identify and understand all of our genes. But that hasn't stopped them from making
dramatic discoveries.
Time. 2000 Jul 3;156(1):24-9. No abstract available.
PMID: 11009718; UI: 20391111
6:
Collins FS, Haseltine WA.
Of genes and genomes: what lies between the base
pairs.
J Investig Med. 2000 Sep;48(5):295-301. No abstract available.
PMID: 10979234; UI: 20433612
7:
Emilien G, Ponchon M, Caldas C, Isacson O, Maloteaux JM.
Impact of genomics
on drug discovery and clinical medicine.
QJM. 2000 Jul;93(7):391-423. Review.
PMID: 10874050; UI: 20334810
8:
Larkin M.
Making sense of genome mania.
Lancet. 2000 Jul 15;356(9225):263.
No abstract available.
PMID: 10963236; UI: 20417226
9:
Bobrow M, Grimbaldeston AH.
Medical genetics, the human genome project and
public health. J Epidemiol Community Health. 2000 Sep;54(9):645-9. No abstract
available.
PMID: 10942439; UI: 20400571
10:
Beller GA.
Presient's page: the human genome project: implications for cardiologists
and their patients.
J Am Coll Cardiol. 2000 Jul;36(1):295-8. No abstract available.
PMID: 10898450; UI: 20354815
Relevant Links
The National Human Genome Research Institute (NHGRI) website: An excellent site which contains a wealth of information about the Human Genome Project and affiliated programs.
The National Center for Biotechnology website: a collection of public databases and software tools for analyzing the human genome.
"PERSONAL PILLS: Genetic differences may dictate how drugs are prescribed" An introduction to pharmacogenomics and how several companies are using the genome to identify for which people a particular drug is safe.
"The Bioinformatics Gold Rush": A $300-million industry has emerged around turning raw genome data into knowledge for making new drugs
The Whitehead Institute at MIT: a wealth of genetics and genomics information.
When and Where:
10 April 2001, 6:00pm, Harvard Medical School, Amphitheatre D.
Click here for a map
Please RSVP to this event.
Links
to Other Policy Roundtable
Series
Discussions:
Consequences
of the Human Genome Project for Medicine and Society
20
February 2001
Genetic
Privacy: Legal and Ethical Frameworks
27 February 2001
Commercializing
the Human Genome: Making Money and Changing the Scientific Enterprise.
5
April 2001
Translating
Genomics into Better Medicine
10
April 2001
Are
Human Beings Born or Made? Screening of the movie GATTACA
11
April 2001
Read
All About It! The Translation of Science into Public Knowledge: Media Coverage
of the Human Genome Project
12 April 2001
Finding
God in the Genome: How Religion Informs the Applications of the Human Genome Project
19 April 2001
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